PF-06424439 methanesulfonate ( —— )

产品货号. M26369 CAS No. 1469284-79-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PF-06424439 methanesulfonate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).
产品描述

PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM). PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate.(In Vivo):PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life.
同义词

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通路

Others
靶点

Other Targets
受体

PI4Kα
研究领域

——
适应症

——

CAS Number

1469284-79-4
分子量

536.1
分子式

C23H30ClN7O4S
纯度

>98% (HPLC)
溶解度

——
SMILES

CS(O)(=O)=O.Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
化学全称

——

1.Anna Lindsey Banka, et al. Quinazolinone derivatives as antiviral agents.WO2012087938A1

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